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Johansson G, Lindberg A, Romberg K, Nordstrom L, Gerken F, Roquet A. Bronchodilator efficacy of tiotropium in patients with mild to moderate COPD. Prim Care Resp J 2008;17(3):169-175. DOI: http://dx.doi.org/10.3132/pcrj.2008.00037
Citation details
Johansson G, Lindberg A, Romberg K, Nordstrom L, Gerken F, Roquet A
Bronchodilator efficacy of tiotropium in patients with mild to moderate COPD
(2008) Prim Care Resp J 17 (3), pp. 169-175.
DOI: http://dx.doi.org/10.3132/pcrj.2008.00037
Article web page: http://www.thepcrj.org/journ/view_article.php?article_id=569
PDF url: http://www.thepcrj.org/journ/vol17/17_3_169_175.pdf
Abstract:
AIMS: Evaluation of tiotropium efficacy in patients with mild chronic obstructive pulmonary disease (COPD) defined by the 2003 Swedish
Society of Respiratory Medicine guidelines (post-bronchodilator FEV1/FVC <70%; FEV1 >60% predicted).
METHODS: In this 12-week, randomised, double-blind, placebo-controlled study of tiotropium 18 mcg once daily versus placebo,
respiratory function was assessed on Days 1, 15 and 85 (baseline: pre-dose Day 1).
RESULTS: Mean+/-SD baseline FEV1 (% predicted) was 73.4+/-12.5 (tiotropium, n=107; placebo, n=117). Tiotropium significantly improved
change from baseline in area under the curve from pre-dose to 2 hours post-dose (AUC0-2 h) FEV1 versus placebo, by 166+/-26 mL
(mean+/-SE) at study end (p<0.0001). With tiotropium, there were significant increases in the change in AUC0-2 h FVC versus baseline,
and trough FEV1 and FVC, versus placebo, on all test days (p<0.01). Adverse event rates were similar.
CONCLUSION: Compared with placebo, tiotropium improved lung function in patients with mild COPD.
Keywords:
Chronic obstructive pulmonary disease, mild, moderate, tiotropium
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