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Volume 17 Issue 3 September 2008Bronchodilator efficacy of tiotropium in patients with mild to moderate COPD • Original Research Pages 169-175 *Gunnar Johanssona, Anne Lindbergb, Kerstin Rombergc, Lars Nordströmd, Fronke Gerkene, Annika Roquetd a Associate Professor, Nyby Healthcare Centre and Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden b Senior Consultant, The OLIN Studies and Division of Respiratory Medicine, Sunderby Hospital, Luleå, Sweden c General Practioner, Näset Healthcare Centre, Höllviken, Sweden d Clinical monitor, Boehringer Ingelheim AB, Stockholm, Sweden e Statistician, Boehringer Ingelheim Pharma GmbH & Co, Ingelheim, Germany Received 21 December 2007 • Accepted 7 May 2008 • Online 6 June 2008 Abstract AIMS: Evaluation of tiotropium efficacy in patients with mild chronic obstructive pulmonary disease (COPD) defined by the 2003 Swedish Society of Respiratory Medicine guidelines (post-bronchodilator FEV1/FVC <70%; FEV1 >60% predicted). METHODS: In this 12-week, randomised, double-blind, placebo-controlled study of tiotropium 18 mcg once daily versus placebo, respiratory function was assessed on Days 1, 15 and 85 (baseline: pre-dose Day 1). RESULTS: Mean±SD baseline FEV1 (% predicted) was 73.4±12.5 (tiotropium, n=107; placebo, n=117). Tiotropium significantly improved change from baseline in area under the curve from pre-dose to 2 hours post-dose (AUC0-2 h) FEV1 versus placebo, by 166±26 mL (mean±SE) at study end (p<0.0001). With tiotropium, there were significant increases in the change in AUC0-2 h FVC versus baseline, and trough FEV1 and FVC, versus placebo, on all test days (p<0.01). Adverse event rates were similar. CONCLUSION: Compared with placebo, tiotropium improved lung function in patients with mild COPD. Keywords Chronic obstructive pulmonary disease, mild, moderate, tiotropium View full text as PDF document Right click on this DOI link and copy link to cite this article (What is a DOI link?) * Corresponding author. Gunnar Johansson Tel: +46 18611 3427 Fax: +46 18511 657 Email: gunnar.johansson@pubcare.uu.se |
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