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Volume 16 Issue 2 April 2007

Review

Inhalation therapy: an historical review

Pages 71-81
*Mark Sanders

Pharmaxis Ltd

Creator of inhalatorium.com

Received 6 November 2006 • Accepted 11 November 2006 • Online 13 March 2007


Abstract
SUMMARY: Inhalation has been employed as a method for delivering medications for more than two thousand years, and the benefits of delivering medication directly to the affected site - the lungs - have been understood for more than two hundred years. At the beginning of the Industrial Revolution, physicians were inventing therapies and experimenting with ideas for devices: it was a time of great creativity. However, by the end of the period the scientist and the regulated pharmaceutical industry had emerged and the role of the physician had been constrained. Few of the devices invented then remain in use today, but many of the principles used are still embodied in modern devices. This review traces the developments produced by the early pioneers who applied their creative thoughts to inhalation therapy, and examines how inhaled drug delivery has progressed. The devices pictured are from www.inhalatorium.com, an online museum of inhalation technologies.

Cite as: Sanders M. Inhalation therapy: an historical review. Prim Care Respir J 2007;16(2):71-81. DOI: http://dx.doi.org/10.3132/pcrj.2007.00017

Keywords
Inhalation therapy; History; Asthma; Devices

* Corresponding author. Mark Sanders Tel: +44 (0)7711 995614 Fax: +44 (0)1582 699732 Email: ms@bethere.co.uk