Primary Care Respiratory Journal

Volume 17 Issue 3 September 2008

Original Research

Bronchodilator efficacy of tiotropium in patients with mild to moderate COPD

Pages 169-175
^*Gunnar Johansson^a, Anne Lindberg^b, Kerstin Romberg^c, Lars Nordström^d, Fronke Gerken^e, Annika Roquet^d

^aAssociate Professor, Nyby Healthcare Centre and Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden

^bSenior Consultant, The OLIN Studies and Division of Respiratory Medicine, Sunderby Hospital, Luleå, Sweden

^cGeneral Practioner, Näset Healthcare Centre, Höllviken, Sweden

^dClinical monitor, Boehringer Ingelheim AB, Stockholm, Sweden

^eStatistician, Boehringer Ingelheim Pharma GmbH & Co, Ingelheim, Germany

Received 21 December 2007 • Accepted 7 May 2008 • Online 6 June 2008

Abstract
AIMS: Evaluation of tiotropium efficacy in patients with mild chronic obstructive pulmonary disease (COPD) defined by the 2003 Swedish Society of Respiratory Medicine guidelines (post-bronchodilator FEV1/FVC <70%; FEV1 >60% predicted). METHODS: In this 12-week, randomised, double-blind, placebo-controlled study of tiotropium 18 mcg once daily versus placebo, respiratory function was assessed on Days 1, 15 and 85 (baseline: pre-dose Day 1). RESULTS: Mean±SD baseline FEV1 (% predicted) was 73.4±12.5 (tiotropium, n=107; placebo, n=117). Tiotropium significantly improved change from baseline in area under the curve from pre-dose to 2 hours post-dose (AUC0-2 h) FEV1 versus placebo, by 166±26 mL (mean±SE) at study end (p<0.0001). With tiotropium, there were significant increases in the change in AUC0-2 h FVC versus baseline, and trough FEV1 and FVC, versus placebo, on all test days (p<0.01). Adverse event rates were similar. CONCLUSION: Compared with placebo, tiotropium improved lung function in patients with mild COPD.

Cite as: Johansson G, Lindberg A, Romberg K, Nordstrom L, Gerken F, Roquet A. Bronchodilator efficacy of tiotropium in patients with mild to moderate COPD. Prim Care Respir J 2008;17(3):169-175. DOI: http://dx.doi.org/10.3132/pcrj.2008.00037

Keywords
Chronic obstructive pulmonary disease, mild, moderate, tiotropium

* Corresponding author. Gunnar Johansson Tel: +46 18611 3427 Fax: +46 18511 657 Email: gunnar.johansson@pubcare.uu.se

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