Volume 20 Issue 4 December 2011
Efficacy of indacaterol in the treatment of patients with COPD
Pages 380-388
*Paul W Jonesa, Neil Barnesb, Claus Vogelmeierc, David Lawrenced, Benjamin Kramere
a
Division of Clinical Sciences, St. George's University of London, London, UK
b
Department of Respiratory Medicine, Barts & The London NHS Trust, London, UK
c
Department for Respiratory Diseases, University of Marburg, Marburg, Germany
d
Novartis Horsham Research Centre, Horsham, UK
e
Novartis Pharmaceuticals, Hanover, NJ, USA
Received 17 March 2011 • Accepted 5 July 2011 • Online 22 July 2011
Abstract
Effective bronchodilation is an important part of the management of patients with chronic obstructive pulmonary disease (COPD) and
can improve breathlessness and ability to undertake physical activities. Indacaterol is a new once-daily, long-acting inhaled bronchodilator
for COPD. We review here the efficacy of indacaterol as a bronchodilator, including its impact upon symptoms and health status. The
evidence reviewed comprises four placebo-controlled clinical studies of indacaterol treatment, three of which included treatment arms
with one of the other long-acting inhaled bronchodilators (once-daily tiotropium or twice-daily salmeterol or formoterol), in 4,833
patients with moderate-to-severe COPD. Indacaterol had a bronchodilator effect significantly greater than formoterol and salmeterol, and
similar to tiotropium. Its effect on symptoms and health status was similar or significantly greater than the other bronchodilators. The
safety profile was similar to placebo. Once-daily indacaterol is an effective and beneficial maintenance bronchodilator treatment for
patients with moderate-to-severe COPD.
Cite as: Jones PW, Barnes N, Vogelmeier C, Lawrence D, Kramer B. Efficacy of indacaterol in the treatment of patients with COPD. Prim Care Respir J 2011;20(4):380-388. DOI: http://dx.doi.org/10.4104/pcrj.2011.00066
Keywords
Indacaterol, efficacy, bronchodilators, COPD, formoterol, salmeterol, tiotropium
* Corresponding author. Paul W Jones Tel: +44 (0)20 8725 5371 Fax: +44 (0)20 8725 5955 Email: pjones@sgul.ac.uk | |
